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In a survey of pooled data from 11 publictions, including a total of 9,766 infertile men, the incidence of chromosomal abnormalities was found to be 5.8% [1]. Of these, sex chromosome abnormalities accounted for 4.2% and autosomal abnormalities for 1.5%. In comparison, the incidence of abnormalities in pooled data from three series totalling 94,465 newborn male infants was 0.38%, of which 131 (0.14%) were sex chromosome abnormalities and 232 (0.25%) were autosomal abnormalities [2]. The possibility of abnormalities increases with increasing severity of impaired spermatogenesis [1,3]. By means of IVF and ICSI techniques, it is now possible for men with very low sperm counts to be given a reasonable chance of paternity. Standard karyotype analysis should be offered to all men with damaged spermatogenesis who are seeking fertility treatment by IVF/ICSI. |
