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However, in the situation where both partners are known to carry defects (e.g. cystic fibrosis mutations), there can be up to a 50% chance of a child from the union developing clinical cystic fibrosis and dying early after a number of years of morbidity. Many clinicians and infertility clinic personnel may feel that their duty of care to the future child and the interests of society as a whole outweigh the wishes of the individual couple and that it is not ethical to proceed. When there is a conflict that cannot be resolved by agreement, the interests of a future child probably take precedence over the interests of a couple. Furthermore, the couple wiD need to give consideration to pre-implantation diagnosis and the replacement only of normal embryos |